ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: J Clin Oncol. 2019;37(32):3018–3031. wassim.chemaitilly@stjude.orgThis retrospective study, with cross-sectional health outcomes analysis, evaluated Leydig cell function in 1516 childhood cancer survivors at a median duration of 22.0 years after cancer diagnosis. These patients are part of the St Jude Lifetime Cohort. An age- and sex-matched community control grou...

Pediatr Blood Cancer. 2020; 67: e28617. https://pubmed.ncbi.nlm.nih.gov/32715632/This retrospective single-centre study aimed to develop a final height prediction model based on data from 212 long-term survivors (aged 5-20.4 years) of childhood central nervous system (CNS) tumors who received craniospinal irradiation (CSI) and with a median follow up of 10.2 years. Mean fin...

To read the full abstract: J Clin Endocrinol Metab. 2018 Aug 1; 103(8):2785GH deficiency (GHD) is common among children treated for cancer, especially among childhood cancer survivors (CCS) with tumors/surgery in the hypothalamic-pituitary (HP) region, CCS exposed to HP radiation or CCS exposed to cranial (CIR), craniospinal (CSI), or total body irradiation (TBI). However, most of existi...

To read the full abstract: J Clin Endocrinol Metab. 2018 Aug 1; 103(8): 2794This systematic review and meta-analysis was conducted by a US Endocrine Society Task Force in order to inform new guidelines on the management of childhood cancer survivors (CCS). The aim of this review was to evaluate the effects of GH therapy on final height, risk of diabetes mellitus, lipid abnormalities, met...

Brief summary: This study used a Delphi approach to generate consensus guidelines for screening of asymptomatic childhood cancer survivors for thyroid dysfunction and recommendations for the management of abnormal thyroid screening results.A Delphi panel of 40 clinical experts (oncologists, endocrinologists, and primary care physicians) participated in three rounds of anonymous questionnaires, formatted as clinical scenarios. Consensus was defined by agr...

To read the full abstract: Lancet Haematol. 2019 Jun; 6(6): e306.The St Jude Lifetime (SJLIFE) Cohort is a retrospective cohort of childhood cancer survivors (CCS), who are followed prospectively in order to evaluate long-term health outcomes. This study evaluated chronic health conditions in 980 childhood lymphoblastic leukaemia survivors of the SJLIFE cohort, compared to 272 matched co...

To read the full abstract: Pediatr Blood Cancer. 2017;64(6):e26338Through a comprehensive, risk-based clinical assessment and validation of medical events, this study provides a detailed heath status characterization of adult survivors of paediatric non-Hodgkin lymphoma (NHL). Survivors showed an increased risk of suffering from one or more components of the metabolic syndrome (obesity 35%, hypertens...

Hum Reprod. 2021; 36: 1120–1133. https://pubmed.ncbi.nlm.nih.gov/33582778/This multi-centre retrospective cohort study identifies that common genetic variants in DNA repair genes modify the damage induced by alkylating agents on ovarian function, as assessed by low AMH levels.Alkylating agents are known to induce apoptosis of cancer cells by damaging DNA replicat...

n.karavitaki@bham.ac.uk Eur J Endocrinol. 2022; 186: P35-P52. PMID: 35319491.Brief Summary: An international panel of experts produced this consensus statement after critical review of the existing evidence on the safety of GH replacement in cancer and intracranial tumour survivors and in patients with increased cancer risk. Current evidence does not support an association betwe...

Brief summary: In this extensive and updated review, the International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG) report expert consensus-based guidelines that harmonize recommendations for surveillance of endocrine disorders in childhood cancer survivors.This interdisciplinary panel of 42 international experts formulated new surveillance recommendations for hypothalamic–pituitary (HP) dysfunction. Existing IGHG surveillan...